Three siderophores from one bacterial enzymatic assembly line.
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ABSTRACT:
SUBMITTER: Wuest WM
PROVIDER: S-EPMC2676571 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Publications
Three siderophores from one bacterial enzymatic assembly line.
Wuest William M WM Sattely Elizabeth S ES Walsh Christopher T CT
Journal of the American Chemical Society 20090401 14
Siderophores play a vital role in the survival of bacteria, as they facilitate the transport of iron in low-concentration environments. Nature employs a variety of coordinating functional groups in siderophore scaffolds as a way of creating structural diversity. We have successfully shown that the pseudomonine synthetase can produce three distinct siderophore natural products and five siderophore-like compounds. The in vitro enzymatic production of acinetobactin has prompted a revision of the re ...[more]
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