Metabolites of cerebellar neurons and hippocampal neurons play opposite roles in pathogenesis of Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Du J
PROVIDER: S-EPMC2677455 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Publications
Metabolites of cerebellar neurons and hippocampal neurons play opposite roles in pathogenesis of Alzheimer's disease.
Du Jing J Sun Bing B Chen Kui K Zhang Lang L Liu Shubo S Gu Qingquan Q Fan Li L Zhao Nanming N Wang Zhao Z
PloS one 20090513 5
Metabolites of neural cells, is known to have a significant effect on the normal physiology and function of neurons in brain. However, whether they play a role in pathogenesis of neurodegenerative diseases is unknown. Here, we show that metabolites of neurons play essential role in the pathogenesis of Alzheimer's disease (AD). Firstly, in vivo and in vitro metabolites of cerebellar neurons both significantly induced the expression of Abeta-degrading enzymes in the hippocampus and cerebral cortex ...[more]
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