Ontology highlight
ABSTRACT:
SUBMITTER: Ashton-Chess J
PROVIDER: S-EPMC2678031 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Ashton-Chess Joanna J Dugast Emilie E Colvin Robert B RB Giral Magali M Foucher Yohann Y Moreau Anne A Renaudin Karine K Braud Christophe C Devys Anne A Brouard Sophie S Soulillou Jean-Paul JP
Journal of the American Society of Nephrology : JASN 20090408 5
Animal studies have suggested a potential role for regulatory T cells (Tregs) in allograft tolerance, but these FOXP3+ cells seem to be an inherent component of acute rejection (AR) in human recipients of renal transplants. The balance between regulatory cells and effector/cytotoxic cells may determine graft outcome; this balance has not been described for chronic allograft injury. We investigated the expression of key regulatory, effector, and cytotoxic transcripts (i.e., FOXP3, T-bet, and gran ...[more]