Ontology highlight
ABSTRACT:
SUBMITTER: Argiriadi MA
PROVIDER: S-EPMC2678131 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Argiriadi Maria A MA Sousa Silvino S Banach David D Marcotte Douglas D Xiang Tao T Tomlinson Medha J MJ Demers Megan M Harris Christopher C Kwak Silvia S Hardman Jennifer J Pietras Margaret M Quinn Lisa L DiMauro Jennifer J Ni Baofu B Mankovich John J Borhani David W DW Talanian Robert V RV Sadhukhan Ramkrishna R
BMC structural biology 20090318
<h4>Background</h4>Structure-based drug design (SBDD) can provide valuable guidance to drug discovery programs. Robust construct design and expression, protein purification and characterization, protein crystallization, and high-resolution diffraction are all needed for rapid, iterative inhibitor design. We describe here robust methods to support SBDD on an oral anti-cytokine drug target, human MAPKAP kinase 2 (MK2). Our goal was to obtain useful diffraction data with a large number of chemicall ...[more]