Ontology highlight
ABSTRACT:
SUBMITTER: Banavar JR
PROVIDER: S-EPMC2678487 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Banavar Jayanth R JR Cieplak Marek M Hoang Trinh Xuan TX Maritan Amos A
Proceedings of the National Academy of Sciences of the United States of America 20090409 17
Learning from nature's amazing molecular machines, globular proteins, we present a framework for the predictive design of nanomachines. We show that the crucial ingredients for a chain molecule to behave as a machine are its inherent anisotropy and the coupling between the local Frenet coordinate reference frames of nearby monomers. We demonstrate that, even in the absence of heterogeneity, protein-like behavior is obtained for a simple chain molecule made up of just 30 hard spheres. This chain ...[more]