Influence of food intake on the bioavailability and efficacy of oral calcitonin.

ABSTRACT:

Aims

To investigate the influence of food intake on the bioavailability and pharmacodynamic effects of salmon calcitonin (sCT).

Methods

A single-blind, randomized, partly placebo-controlled study was conducted in 36 healthy postmenopausal female volunteers aged 62-74 years. The influence of food intake on oral dosing with 0.8 mg of sCT at 22.00 h was evaluated for a (i) predose meal at 18.00 h, (ii) predose meal at 20.00 h, (iii) predose meal at 21.00 h, (iv) postdose meal at 22.10 h, (v) no meal, and (vi) meal at 20.00 h and placebo at 22.00 h. Study biomarkers were plasma sCT levels and changes in the bone resorption marker CTX-I (C-terminal telopeptide of collagen type I).

Results

The predose meal at 18.00 and 21.00 h significantly decreased relative oral bioavaila

SUBMITTER: Karsdal MA 

PROVIDER: S-EPMC2679104 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature