Reversing adipocyte differentiation: implications for treatment of obesity.
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ABSTRACT:
SUBMITTER: Zhou YT
PROVIDER: S-EPMC26794 | biostudies-literature | 1999 Mar
REPOSITORIES: biostudies-literature
Publications
Reversing adipocyte differentiation: implications for treatment of obesity.
Zhou Y T YT Wang Z W ZW Higa M M Newgard C B CB Unger R H RH
Proceedings of the National Academy of Sciences of the United States of America 19990301 5
Conventional treatment of obesity reduces fat in mature adipocytes but leaves them with lipogenic enzymes capable of rapid resynthesis of fat, a likely factor in treatment failure. Adenovirus-induced hyperleptinemia in normal rats results in rapid nonketotic fat loss that persists after hyperleptinemia disappears, whereas pair-fed controls regain their weight in 2 weeks. We report here that the hyperleptinemia depletes adipocyte fat while profoundly down-regulating lipogenic enzymes and their tr ...[more]
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2022-01-22 | GSE181477 | GEO