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Protein ionizable groups: pK values and their contribution to protein stability and solubility.

ABSTRACT: The structure, stability, solubility, and function of proteins depend on their net charge and on the ionization state of the individual residues. Consequently, biochemists are interested in the pK values of the ionizable groups in proteins and how these pK values depend on their environment. We review what has been learned about pK values of ionizable groups in proteins from experimental studies and discuss the important contributions they make to protein stability and solubility.

SUBMITTER: Pace CN

PROVIDER: S-EPMC2679426 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

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Protein ionizable groups: pK values and their contribution to protein stability and solubility.

Pace C Nick CN Grimsley Gerald R GR Scholtz J Martin JM

The Journal of biological chemistry 20090121 20

The structure, stability, solubility, and function of proteins depend on their net charge and on the ionization state of the individual residues. Consequently, biochemists are interested in the pK values of the ionizable groups in proteins and how these pK values depend on their environment. We review what has been learned about pK values of ionizable groups in proteins from experimental studies and discuss the important contributions they make to protein stability and solubility. ...[more]

PMID: 19164280

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