Ontology highlight
ABSTRACT:
SUBMITTER: McCarty KM
PROVIDER: S-EPMC2679598 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
McCarty Kathleen M KM Santella Regina M RM Steck Susan E SE Cleveland Rebecca J RJ Ahn Jiyoung J Ambrosone Christine B CB North Kari K Sagiv Sharon K SK Eng Sybil M SM Teitelbaum Susan L SL Neugut Alfred I AI Gammon Marilie D MD
Environmental health perspectives 20081210 4
<h4>Background</h4>Polycyclic aromatic hydrocarbons (PAHs) may increase breast cancer risk, and the association may be modified by inherited differences in deactivation of PAH intermediates by glutathione S-transferases (GSTs). Few breast cancer studies have investigated the joint effects of multiple GSTs and a PAH biomarker.<h4>Objective</h4>We estimated the breast cancer risk associated with multiple polymorphisms in the GST gene (GSTA1, GSTM1, GSTP1, and GSTT1) and the interaction with PAH-DN ...[more]