Ontology highlight
ABSTRACT:
SUBMITTER: Nakamura Y
PROVIDER: S-EPMC2680316 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Nakamura Yasushi Y Kominami Akari A Tsujimoto Yoshiyuki Y Nakayama Yuko Y Kitahashi Tsukasa T Yoshimoto Sonoko S Kubo Asuka A Watanabe Shinpei S Kageyama Minami M Yokoyama Meiko M Kido Yasuhiro Y Kobayashi Yukiko Y Kuwahata Masashi M Chang Chia-Cheng CC Upham Brad L BL Trosko James E JE Park Eun Young EY Sato Kenji K
International journal of cancer 20090601 11
The introduction of the tumorigenic v-Ha-ras oncogene-transformed rat liver epithelial cells (WBras), which is deficient in gap junctional intercellular communication (GJIC), into F344 rats, induces significant formation of hepatocellular tumors. GJIC plays a major role in maintaining tissue homeostasis. Using this in vivo tumor model system, we used 2-dimensional electrophoresis with isoelectric focusing in the first dimension and SDS-PAGE in the second dimension to globally identify proteins t ...[more]