A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation.
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ABSTRACT:
SUBMITTER: Schuman J
PROVIDER: S-EPMC2680363 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
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A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation.
Schuman James J Chen Yuhong Y Podd Andrew A Yu Mei M Liu Hong-Hsing HH Wen Renren R Chen Zhijian J ZJ Wang Demin D
Blood 20090205 19
The kinase TAK1 is essential for T-cell receptor (TCR)-mediated nuclear factor kappaB (NF-kappaB) activation and T-cell development. However, the role of TAK1 in B-cell receptor (BCR)-mediated NF-kappaB activation and B-cell development is not clear. Here we show that B-cell-specific deletion of TAK1 impaired the transition from transitional type 2 to mature follicular (FO) B cells and caused a marked decrease of marginal zone (MZ) B cells. TAK1-deficient B cells exhibited an increase of BCR-ind ...[more]
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