Ontology highlight
ABSTRACT:
SUBMITTER: Ellis T
PROVIDER: S-EPMC2680460 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Ellis Tom T Wang Xiao X Collins James J JJ
Nature biotechnology 20090419 5
Engineering artificial gene networks from modular components is a major goal of synthetic biology. However, the construction of gene networks with predictable functions remains hampered by a lack of suitable components and the fact that assembled networks often require extensive, iterative retrofitting to work as intended. Here we present an approach that couples libraries of diversified components (synthesized with randomized nonessential sequence) with in silico modeling to guide predictable g ...[more]