MicroRNA-mediated inhibition of prostate-derived Ets factor messenger RNA translation affects prostate-derived Ets factor regulatory networks in human breast cancer.
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ABSTRACT:
SUBMITTER: Findlay VJ
PROVIDER: S-EPMC2680499 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Publications
MicroRNA-mediated inhibition of prostate-derived Ets factor messenger RNA translation affects prostate-derived Ets factor regulatory networks in human breast cancer.
Findlay Victoria J VJ Turner David P DP Moussa Omar O Watson Dennis K DK
Cancer research 20081001 20
Prostate-derived Ets factor (PDEF) is an ETS transcription factor expressed in normal tissues with high epithelial cell content and noninvasive breast cancer cells. A putative tumor suppressor PDEF protein expression is often lost during progression to a more invasive phenotype. Interestingly, PDEF mRNA has been found to be retained or even overexpressed in the absence of protein; however, the mechanisms for this remain to be elucidated. This study identifies two microRNAs (miRNA) that directly ...[more]
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