Ontology highlight
ABSTRACT:
SUBMITTER: Reijns MA
PROVIDER: S-EPMC2680509 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Journal of cell science 20080708 Pt 15
P-bodies are cytoplasmic foci that are sites of mRNA degradation and translational repression. It is not known what causes the accumulation of RNA-degradation factors in P-bodies, although RNA is required. The yeast Lsm1-7p complex (comprising Lsm1p to Lsm7p) is recruited to P-bodies under certain stress conditions. It is required for efficient decapping and degradation of mRNAs, but not for the assembly of P-bodies. Here we show that the Lsm4p subunit and its asparagine-rich C-terminus are pron ...[more]