Ontology highlight
ABSTRACT:
SUBMITTER: Andrew AS
PROVIDER: S-EPMC2680739 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Andrew Angeline S AS Mason Rebecca A RA Kelsey Karl T KT Schned Alan R AR Marsit Carmen J CJ Nelson Heather H HH Karagas Margaret R MR
Toxicology letters 20090120 1
Drinking water arsenic exposure has been associated with increased bladder cancer susceptibility. Epidemiologic and experimental data suggest a co-carcinogenic effect of arsenic with exposure to DNA damaging agents, such as cigarette smoke. Recent evidence further supports the hypothesis that genetic variation in DNA repair genes can modify the arsenic-cancer relationship, possibly because arsenic impairs DNA repair capacity. We tested this hypothesis in a population-based study of bladder cance ...[more]