Multilocus Bayesian meta-analysis of gene-disease associations.
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ABSTRACT:
SUBMITTER: Newcombe PJ
PROVIDER: S-EPMC2680997 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Publications
Multilocus Bayesian meta-analysis of gene-disease associations.
Newcombe Paul J PJ Verzilli Claudio C Casas Juan P JP Hingorani Aroon D AD Smeeth Liam L Whittaker John C JC
American journal of human genetics 20090430 5
Meta-analysis is a vital tool in genetic epidemiology. However, meta-analyses to identify gene-disease associations are compromised when contributing studies have typed partially overlapping sets of markers. Currently, only marginal analyses are possible, and these are restricted to the subset of studies typing that marker. This does not allow full use of available data and leads to the confounding of marker effects by closely associated markers. We present a Bayesian approach that exploits prio ...[more]
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