Ontology highlight
ABSTRACT:
SUBMITTER: Williams RS
PROVIDER: S-EPMC2681233 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Williams R Scott RS Moncalian Gabriel G Williams Jessica S JS Yamada Yoshiki Y Limbo Oliver O Shin David S DS Groocock Lynda M LM Cahill Dana D Hitomi Chiharu C Guenther Grant G Moiani Davide D Carney James P JP Russell Paul P Tainer John A JA
Cell 20081001 1
Mre11 forms the core of the multifunctional Mre11-Rad50-Nbs1 (MRN) complex that detects DNA double-strand breaks (DSBs), activates the ATM checkpoint kinase, and initiates homologous recombination (HR) repair of DSBs. To define the roles of Mre11 in both DNA bridging and nucleolytic processing during initiation of DSB repair, we combined small-angle X-ray scattering (SAXS) and crystal structures of Pyrococcus furiosus Mre11 dimers bound to DNA with mutational analyses of fission yeast Mre11. The ...[more]