Ontology highlight
ABSTRACT:
SUBMITTER: Shroff EH
PROVIDER: S-EPMC2681411 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
PloS one 20090521 5
BH3 only proteins trigger cell death by interacting with pro- and anti-apoptotic members of the BCL-2 family of proteins. Here we report that BH3 peptides corresponding to the death domain of BH3-only proteins, which bind all the pro-survival BCL-2 family proteins, induce cell death in the absence of BAX and BAK. The BH3 peptides did not cause the release of cytochrome c from isolated mitochondria or from mitochondria in cells. However, the BH3 peptides did cause a decrease in mitochondrial memb ...[more]