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Glycerol utilization gene cluster in Streptomyces clavuligerus.

ABSTRACT: The Streptomyces clavuligerus ATCC 27064 glycerol cluster gylR-glpF1K1D1 is induced by glycerol but is not affected by glucose. S. clavuligerus growth and clavulanic acid production are stimulated by glycerol, but this does not occur in a glpK1-deleted mutant. Amplification of glpK1D1 results in transformants yielding larger amounts of clavulanic acid in the wild-type strain and in overproducer S. clavuligerus Gap15-7-30 or S. clavuligerus Delta relA strains.

SUBMITTER: Banos S

PROVIDER: S-EPMC2681673 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

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Glycerol utilization gene cluster in Streptomyces clavuligerus.

Baños Sonia S Pérez-Redondo Rosario R Koekman Bert B Liras Paloma P

Applied and environmental microbiology 20090313 9

The Streptomyces clavuligerus ATCC 27064 glycerol cluster gylR-glpF1K1D1 is induced by glycerol but is not affected by glucose. S. clavuligerus growth and clavulanic acid production are stimulated by glycerol, but this does not occur in a glpK1-deleted mutant. Amplification of glpK1D1 results in transformants yielding larger amounts of clavulanic acid in the wild-type strain and in overproducer S. clavuligerus Gap15-7-30 or S. clavuligerus Delta relA strains. ...[more]

PMID: 19286797

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