Ontology highlight
ABSTRACT:
SUBMITTER: Cornelius CA
PROVIDER: S-EPMC2681732 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Infection and immunity 20090223 5
Yersinia pestis is perhaps the most feared infectious agent due to its ability to cause epidemic outbreaks of plague disease in animals and humans with high mortality. Plague infections elicit strong humoral immune responses against the capsular antigen (fraction 1 [F1]) of Y. pestis, and F1-specific antibodies provide protective immunity. Here we asked whether Y. pestis generates mutations that enable bacterial escape from protective immunity and isolated a variant with an IS1541 insertion in c ...[more]