Ontology highlight
ABSTRACT:
SUBMITTER: Zielenkiewicz U
PROVIDER: S-EPMC2681916 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Zielenkiewicz Urszula U Kowalewska Magdalena M Kaczor Celina C Ceglowski Piotr P
Journal of bacteriology 20090403 11
The widespread prokaryotic toxin-antitoxin (TA) systems involve conditional interaction between two TA proteins. The interaction between the Epsilon and Zeta proteins, constituting the TA system of plasmid pSM19035 from Streptococcus pyogenes, was detected in vivo using a yeast two-hybrid system. As we showed using Saccharomyces cerevisiae, the Zeta toxin hybrid gene also exerts its toxic effects in a dose-dependent manner in eukaryotic cells. Analysis of mutant proteins in the two-hybrid system ...[more]