Ontology highlight
ABSTRACT:
SUBMITTER: Katsanou V
PROVIDER: S-EPMC2682039 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Katsanou Vicky V Milatos Stavros S Yiakouvaki Anthie A Sgantzis Nikos N Kotsoni Anastasia A Alexiou Maria M Harokopos Vaggelis V Aidinis Vassilis V Hemberger Myriam M Kontoyiannis Dimitris L DL
Molecular and cellular biology 20090323 10
HuR is an RNA-binding protein implicated in a diverse array of pathophysiological processes due to its effects on the posttranscriptional regulation of AU- and U-rich mRNAs. Here we reveal HuR's requirement in embryonic development through its genetic ablation. Obligatory HuR-null embryos exhibited a stage retardation phenotype and failed to survive beyond midgestation. By means of conditional transgenesis, we restricted HuR's mutation in either embryonic or endothelial compartments to demonstra ...[more]