Ontology highlight
ABSTRACT:
SUBMITTER: Cairrao F
PROVIDER: S-EPMC2682044 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Cairrao Fatima F Halees Anason S AS Khabar Khalid S A KS Morello Dominique D Vanzo Nathalie N
Molecular and cellular biology 20090309 10
In mammals, AU-rich elements (AREs) are critical regulators of mRNA turnover. They recruit ARE-binding proteins that inhibit or stimulate rapid mRNA degradation in response to stress or developmental cues. Using a bioinformatics approach, we have identified AREs in Drosophila melanogaster 3' untranslated regions and validated their cross-species conservation in distant Drosophila genomes. We have generated a Drosophila ARE database (D-ARED) and established that about 16% of D. melanogaster genes ...[more]