Ontology highlight
ABSTRACT:
SUBMITTER: Ponsioen B
PROVIDER: S-EPMC2682048 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Molecular and cellular biology 20090309 10
Epac1 is a guanine nucleotide exchange factor (GEF) for the small G protein Rap and is directly activated by cyclic AMP (cAMP). Upon cAMP binding, Epac1 undergoes a conformational change that allows the interaction of its GEF domain with Rap, resulting in Rap activation and subsequent downstream effects, including integrin-mediated cell adhesion and cell-cell junction formation. Here, we report that cAMP also induces the translocation of Epac1 toward the plasma membrane. Combining high-resolutio ...[more]