Ontology highlight
ABSTRACT:
SUBMITTER: Freathy RM
PROVIDER: S-EPMC2682672 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Freathy Rachel M RM Bennett Amanda J AJ Ring Susan M SM Shields Beverley B Groves Christopher J CJ Timpson Nicholas J NJ Weedon Michael N MN Zeggini Eleftheria E Lindgren Cecilia M CM Lango Hana H Perry John R B JR Pouta Anneli A Ruokonen Aimo A Hyppönen Elina E Power Chris C Elliott Paul P Strachan David P DP Järvelin Marjo-Riitta MR Smith George Davey GD McCarthy Mark I MI Frayling Timothy M TM Hattersley Andrew T AT
Diabetes 20090219 6
<h4>Objective</h4>Low birth weight is associated with an increased risk of type 2 diabetes. The mechanisms underlying this association are unknown and may represent intrauterine programming or two phenotypes of one genotype. The fetal insulin hypothesis proposes that common genetic variants that reduce insulin secretion or action may predispose to type 2 diabetes and also reduce birth weight, since insulin is a key fetal growth factor. We tested whether common genetic variants that predispose to ...[more]