Ontology highlight
ABSTRACT:
SUBMITTER: Dzamba BJ
PROVIDER: S-EPMC2682918 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Dzamba Bette J BJ Jakab Karoly R KR Marsden Mungo M Schwartz Martin A MA DeSimone Douglas W DW
Developmental cell 20090301 3
In this study we demonstrate that planar cell polarity signaling regulates morphogenesis in Xenopus embryos in part through the assembly of the fibronectin (FN) matrix. We outline a regulatory pathway that includes cadherin adhesion and signaling through Rac and Pak, culminating in actin reorganization, myosin contractility, and tissue tension, which, in turn, directs the correct spatiotemporal localization of FN into a fibrillar matrix. Increased mechanical tension promotes FN fibril assembly i ...[more]