Ontology highlight
ABSTRACT:
SUBMITTER: Siegel TN
PROVIDER: S-EPMC2682952 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Siegel T Nicolai TN Hekstra Doeke R DR Kemp Louise E LE Figueiredo Luisa M LM Lowell Joanna E JE Fenyo David D Wang Xuning X Dewell Scott S Cross George A M GA
Genes & development 20090415 9
Unusually for a eukaryote, genes transcribed by RNA polymerase II (pol II) in Trypanosoma brucei are arranged in polycistronic transcription units. With one exception, no pol II promoter motifs have been identified, and how transcription is initiated remains an enigma. T. brucei has four histone variants: H2AZ, H2BV, H3V, and H4V. Using chromatin immunoprecipitation (ChIP) and sequencing (ChIP-seq) to examine the genome-wide distribution of chromatin components, we show that histones H4K10ac, H2 ...[more]