Neural precursor cells and central nervous system radiation sensitivity.
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ABSTRACT:
SUBMITTER: Fike JR
PROVIDER: S-EPMC2683587 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Publications
Neural precursor cells and central nervous system radiation sensitivity.
Fike John R JR Rosi Susanna S Limoli Charles L CL
Seminars in radiation oncology 20090401 2
The tolerance of normal brain tissues limits the radiation dose that can be delivered safely during cranial radiotherapy, and one of the potential complications that can arise involves cognitive impairment. Extensive laboratory data have appeared recently showing that hippocampal neurogenesis is significantly impacted by irradiation and that such changes are associated with altered cognitive function and involve, in part, changes in the microenvironment (oxidative stress and inflammation). Altho ...[more]
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