Ontology highlight
ABSTRACT:
SUBMITTER: Topisirovic I
PROVIDER: S-EPMC2683702 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Topisirovic Ivan I Siddiqui Nadeem N Lapointe Vincent Leroux VL Trost Matthias M Thibault Pierre P Bangeranye Catherine C Piñol-Roma Serafin S Borden Katherine L B KL
The EMBO journal 20090305 8
The eukaryotic translation initiation factor 4E (eIF4E) controls gene expression through its effects on mRNA export and cap-dependent translation, both of which contribute to its oncogenic potential. In contrast to its translation function, the mRNA export function of eIF4E is poorly understood. Using an RNP isolation/mass spectrometry approach, we identified candidate cofactors of eIF4E mRNA export including LRPPRC. This protein associates with mRNAs containing the eIF4E-sensitivity element (4E ...[more]