Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC2683764 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Zhang Jiangyang J Zhang Jiangyang J Jones Melina M DeBoy Cynthia A CA Reich Daniel S DS Farrell Jonathan A D JA Hoffman Paul N PN Griffin John W JW Sheikh Kazim A KA Miller Michael I MI Mori Susumu S Calabresi Peter A PA
The Journal of neuroscience : the official journal of the Society for Neuroscience 20090301 10
Diffusion tensor imaging (DTI) and immunohistochemistry were used to examine axon injury in the rat spinal cord after unilateral L(2)-L(4) dorsal root axotomy at multiple time points (from 16 h to 30 d after surgery). Three days after axotomy, DTI revealed a lesion in the ipsilateral dorsal column extending from the lumbar to the cervical cord. The lesion showed significantly reduced parallel diffusivity and increased perpendicular diffusivity at day 3 compared with the contralateral unlesioned ...[more]