Ontology highlight
ABSTRACT:
SUBMITTER: Bolanos-Garcia VM
PROVIDER: S-EPMC2683949 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Bolanos-Garcia Victor M VM Kiyomitsu Tomomi T D'Arcy Sheena S Chirgadze Dimitri Y DY Grossmann J Günter JG Matak-Vinkovic Dijana D Venkitaraman Ashok R AR Yanagida Mitsuhiro M Robinson Carol V CV Blundell Tom L TL
Structure (London, England : 1993) 20090101 1
The interaction of the central mitotic checkpoint component BUB1 with the mitotic kinetochore protein Blinkin is required for the kinetochore localization and function of BUB1 in the mitotic spindle assembly checkpoint, the regulatory mechanism of the cell cycle that ensures the even distribution of chromosomes during the transition from metaphase to anaphase. Here, we report the 1.74 angstroms resolution crystal structure of the N-terminal region of BUB1. The structure is organized as a tandem ...[more]