Ontology highlight
ABSTRACT:
SUBMITTER: Kadri Z
PROVIDER: S-EPMC2684697 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Kadri Zahra Z Shimizu Ritsuko R Ohneda Osamu O Maouche-Chretien Leila L Gisselbrecht Sylvie S Yamamoto Masayuki M Romeo Paul-Henri PH Leboulch Philippe P Chretien Stany S
PLoS biology 20090609 6
How cell proliferation subsides as cells terminally differentiate remains largely enigmatic, although this phenomenon is central to the existence of multicellular organisms. Here, we show that GATA-1, the master transcription factor of erythropoiesis, forms a tricomplex with the retinoblastoma protein (pRb) and E2F-2. This interaction requires a LXCXE motif that is evolutionary conserved among GATA-1 orthologs yet absent from the other GATA family members. GATA-1/pRb/E2F-2 complex formation stal ...[more]