High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial.

ABSTRACT:

Context

Blood levels of homocysteine may be increased in Alzheimer disease (AD) and hyperhomocysteinemia may contribute to disease pathophysiology by vascular and direct neurotoxic mechanisms. Even in the absence of vitamin deficiency, homocysteine levels can be reduced by administration of high-dose supplements of folic acid and vitamins B(6) and B(12). Prior studies of B vitamins to reduce homocysteine in AD have not had sufficient size or duration to assess their effect on cognitive decline.

Objective

To determine the efficacy and safety of B vitamin supplementation in the treatment of AD.

Design, setting, and patients

A multicenter, randomized, double-blind controlled clinical trial of high-dose folate, vitamin B(6), and vitamin B(12) supplementation in 409 (of 60

SUBMITTER: Aisen PS 

PROVIDER: S-EPMC2684821 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature