Ontology highlight
ABSTRACT:
SUBMITTER: Morris MJ
PROVIDER: S-EPMC2684850 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Morris Michael J MJ Pandit-Taskar Neeta N Carrasquillo Jorge J Divgi Chaitanya R CR Slovin Susan S Kelly William K WK Rathkopf Dana D Gignac Gretchen A GA Solit David D Schwartz Lawrence L Stephenson Ryan D RD Hong Christina C Delacruz Anthony A Curley Tracy T Heller Glenn G Jia Xiaoyu X O'Donoghue Joseph J Larson Steven S Scher Howard I HI
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090413 15
<h4>Purpose</h4>Early studies of patients with castration-resistant metastatic prostate cancer (CRMPC) suggest that chemotherapy administered with a dose of a bone-seeking radiopharmaceutical is superior to chemotherapy alone. To build on this strategy and fully integrate a repetitively dosed bone-seeking radiopharmaceutical into a contemporary chemotherapy regimen, we conducted a phase I study of docetaxel and samarium-153 ((153)Sm) lexidronam.<h4>Patients and methods</h4>Men with progressive C ...[more]