Ontology highlight
ABSTRACT:
SUBMITTER: Cai SQ
PROVIDER: S-EPMC2685168 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Cai Shi-Qing SQ Sesti Federico F
Nature neuroscience 20090329 5
Potassium channels are key regulators of neuronal excitability. Here we show that oxidation of the K(+) channel KVS-1 during aging causes sensory function loss in Caenorhabditis elegans and that protection of this channel from oxidation preserves neuronal function. Chemotaxis, a function controlled by KVS-1, was significantly impaired in worms exposed to oxidizing agents, but only moderately affected in worms harboring an oxidation-resistant KVS-1 mutant (C113S). In aging C113S transgenic worms, ...[more]