Ontology highlight
ABSTRACT:
SUBMITTER: Grandl J
PROVIDER: S-EPMC2685190 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Nature neuroscience 20080901 9
Ion channels can be activated (gated) by a variety of stimuli, including chemicals, voltage, mechanical force or temperature. Although molecular mechanisms of ion channel gating by chemical and voltage stimuli are understood in principal, the mechanisms of temperature activation remain unknown. The transient receptor potential channel TRPV3 is a nonselective cation channel that is activated by warm temperatures and sensory chemicals such as camphor. Here we screened approcimately 14,000 random m ...[more]