Ontology highlight
ABSTRACT:
SUBMITTER: Zhang DL
PROVIDER: S-EPMC2685206 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Zhang De-Liang DL Hughes Robert M RM Ollivierre-Wilson Hayden H Ghosh Manik C MC Rouault Tracey A TA
Cell metabolism 20090501 5
Ferroportin (FPN1), the sole characterized mammalian iron exporter, has an iron-responsive element (IRE) in its 5' untranslated region, which ensures that its translation is repressed by iron regulatory proteins (IRPs) in iron-deficient conditions to maintain cellular iron content. However, here we demonstrate that duodenal epithelial and erythroid precursor cells utilize an alternative upstream promoter to express a FPN1 transcript, FPN1B, which lacks the IRE and is not repressed in iron-defici ...[more]