Structure and orientation of troponin in the thin filament.
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ABSTRACT:
SUBMITTER: Paul DM
PROVIDER: S-EPMC2685683 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Publications
Structure and orientation of troponin in the thin filament.
Paul Danielle M DM Morris Edward P EP Kensler Robert W RW Squire John M JM Squire John M JM
The Journal of biological chemistry 20090324 22
The troponin complex on the thin filament plays a crucial role in the regulation of muscle contraction. However, the precise location of troponin relative to actin and tropomyosin remains uncertain. We have developed a method of reconstructing thin filaments using single particle analysis that does not impose the helical symmetry of actin and is independent of a starting model. We present a single particle three-dimensional reconstruction of the thin filament. Atomic models of the F-actin filame ...[more]
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