Ontology highlight
ABSTRACT:
SUBMITTER: Hardin JW
PROVIDER: S-EPMC2685712 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Hardin John W JW Reyes Francis E FE Batey Robert T RT
The Journal of biological chemistry 20090331 22
In archaea and eukarya, box C/D ribonucleoprotein (RNP) complexes are responsible for 2'-O-methylation of tRNAs and rRNAs. The archaeal box C/D small RNP complex requires a small RNA component (sRNA) possessing Watson-Crick complementarity to the target RNA along with three proteins: L7Ae, Nop5p, and fibrillarin. Transfer of a methyl group from S-adenosylmethionine to the target RNA is performed by fibrillarin, which by itself has no affinity for the sRNA-target duplex. Instead, it is targeted t ...[more]