Population-level effect of potential HSV2 prophylactic vaccines on HIV incidence in sub-Saharan Africa.
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ABSTRACT:
SUBMITTER: Freeman EE
PROVIDER: S-EPMC2686080 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Publications
Population-level effect of potential HSV2 prophylactic vaccines on HIV incidence in sub-Saharan Africa.
Freeman Esther E EE White Richard G RG Bakker Roel R Orroth Kate K KK Weiss Helen A HA Buvé Anne A Hayes Richard J RJ Glynn Judith R JR
Vaccine 20081209 6
Herpes simplex virus type-2 (HSV2) infection increases HIV transmission. We explore the impact of a potential prophylactic HSV2 vaccination on HIV incidence in Africa using STDSIM an individual-based model. A campaign that achieved 70% coverage over 5 years with a vaccine that reduced susceptibility to HSV2 acquisition and HSV2 reactivation by 75% for 10 years, reduced HIV incidence by 30-40% after 20 years (range 4-66%). Over 20 years, in most scenarios fewer than 100 vaccinations were required ...[more]
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