Ontology highlight
ABSTRACT:
SUBMITTER: Martin PJ
PROVIDER: S-EPMC2686178 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Martin Paul J PJ Storer Barry E BE Rowley Scott D SD Flowers Mary E D ME Lee Stephanie J SJ Carpenter Paul A PA Wingard John R JR Shaughnessy Paul J PJ DeVetten Marcel P MP Jagasia Madan M Fay Joseph W JW van Besien Koen K Gupta Vikas V Kitko Carrie C Johnston Laura J LJ Maziarz Richard T RT Arora Mukta M Jacobson Pamala A PA Weisdorf Daniel D
Blood 20090306 21
We conducted a double-blind, randomized multicenter trial to determine whether the addition of mycophenolate mofetil (MMF) improves the efficacy of initial systemic treatment of chronic graft-versus-host disease (GVHD). The primary endpoint was resolution of chronic GVHD and withdrawal of all systemic treatment within 2 years, without secondary treatment. Enrollment of 230 patients was planned, providing 90% power to observe a 20% difference in success rates between the 2 arms. The study was clo ...[more]