Unknown

Dataset Information

0

Gag- and Nef-specific CD4+ T cells recognize and inhibit SIV replication in infected macrophages early after infection.


ABSTRACT: The precise immunological role played by CD4(+) T cells in retroviral infections is poorly defined. Here, we describe a new function of these cells, the elimination of retrovirus-infected macrophages. After experimental CD8(+) cell depletion, elite controlling macaques with set-point viral loads < or = 500 viral RNA copies/mL mounted robust Gag- and Nef-specific CD4(+) T cell responses during reestablishment of control with > or = 54% of all virus-specific CD4(+) T cells targeting these 2 proteins. Ex vivo, these simian immunodeficiency virus (SIV)-specific CD4(+) T cells neither recognized nor suppressed viral replication in SIV-infected CD4(+) T cells. In contrast, they recognized SIV-infected macrophages as early as 2 h postinfection because of presentation of epitopes derived from virion-associated Gag and Nef proteins. Furthermore, virus-specific CD4(+) T cells displayed direct effector function and eliminated SIV-infected macrophages. These results suggest that retrovirus-specific CD4(+) T cells may contribute directly to elite control by inhibiting viral replication in macrophages.

SUBMITTER: Sacha JB 

PROVIDER: S-EPMC2687996 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC4860118 | biostudies-literature
| S-EPMC6013218 | biostudies-literature
| S-EPMC5313072 | biostudies-literature
| S-EPMC7605674 | biostudies-literature
| S-EPMC3861532 | biostudies-literature
| S-EPMC3372643 | biostudies-literature
| S-EPMC7190186 | biostudies-literature
| S-EPMC6183272 | biostudies-literature
| S-EPMC2267008 | biostudies-literature
| S-EPMC7210278 | biostudies-literature