Ontology highlight
ABSTRACT:
SUBMITTER: Korbel JO
PROVIDER: S-EPMC2688268 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Korbel Jan O JO Abyzov Alexej A Mu Xinmeng Jasmine XJ Carriero Nicholas N Cayting Philip P Zhang Zhengdong Z Snyder Michael M Gerstein Mark B MB
Genome biology 20090223 2
Personal-genomics endeavors, such as the 1000 Genomes project, are generating maps of genomic structural variants by analyzing ends of massively sequenced genome fragments. To process these we developed Paired-End Mapper (PEMer; http://sv.gersteinlab.org/pemer). This comprises an analysis pipeline, compatible with several next-generation sequencing platforms; simulation-based error models, yielding confidence-values for each structural variant; and a back-end database. The simulations demonstrat ...[more]