Ontology highlight
ABSTRACT:
SUBMITTER: Klechevsky E
PROVIDER: S-EPMC2688399 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Klechevsky Eynav E Morita Rimpei R Liu Maochang M Cao Yanying Y Coquery Sebastien S Thompson-Snipes Luann L Briere Francine F Chaussabel Damien D Zurawski Gerard G Palucka A Karolina AK Reiter Yoram Y Banchereau Jacques J Ueno Hideki H
Immunity 20080901 3
Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207(+) Langerhans cells (LCs) and dermal CD14(+) DCs. We showed that CD14(+) DCs primed CD4(+) T cells into cells that induce naive B cells to switch isotype and become plasma cells. In contrast, LCs preferentially induced the differentiation of CD4(+) T cells secreting T helper 2 (Th2) cell cytokines and were efficient at priming and crosspriming naive CD8(+) T cells. A third ...[more]