Ontology highlight
ABSTRACT:
SUBMITTER: Wheeler D
PROVIDER: S-EPMC2688711 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Wheeler David D Knapp Edward E Bandaru Veera V R VV Wang Yue Y Knorr David D Poirier Christophe C Mattson Mark P MP Geiger Jonathan D JD Haughey Norman J NJ
Journal of neurochemistry 20090314 5
The insertion and removal of NMDA receptors from the synapse are critical events that modulate synaptic plasticity. While a great deal of progress has been made on understanding the mechanisms that modulate trafficking of NMDA receptors, we do not currently understand the molecular events required for the fusion of receptor containing vesicles with the plasma membrane. Here, we show that sphingomyelin phosphodiesterase 3 (also known as neutral sphingomyelinase-2) is critical for tumor necrosis f ...[more]