Chromatin conformation signatures of cellular differentiation.
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ABSTRACT:
SUBMITTER: Fraser J
PROVIDER: S-EPMC2688928 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Publications
Chromatin conformation signatures of cellular differentiation.
Fraser James J Rousseau Mathieu M Shenker Solomon S Ferraiuolo Maria A MA Hayashizaki Yoshihide Y Blanchette Mathieu M Dostie Josée J
Genome biology 20090419 4
One of the major genomics challenges is to better understand how correct gene expression is orchestrated. Recent studies have shown how spatial chromatin organization is critical in the regulation of gene expression. Here, we developed a suite of computer programs to identify chromatin conformation signatures with 5C technology http://Dostielab.biochem.mcgill.ca. We identified dynamic HoxA cluster chromatin conformation signatures associated with cellular differentiation. Genome-wide chromatin c ...[more]
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