Ontology highlight
ABSTRACT:
SUBMITTER: Manzano D
PROVIDER: S-EPMC2689023 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Manzano David D Marquardt Sebastian S Jones Alexandra M E AM Bäurle Isabel I Liu Fuquan F Dean Caroline C
Proceedings of the National Academy of Sciences of the United States of America 20090513 21
The role of RNA metabolism in chromatin silencing is now widely recognized. We have studied the Arabidopsis RNA-binding protein FCA that down-regulates an endogenous floral repressor gene through a chromatin mechanism involving histone demethylase activity. This mechanism needs FCA to interact with an RNA 3' processing/polyadenylation factor (FY/Pfs2p), but the subsequent events leading to chromatin changes are unknown. Here, we show that this FCA-FY interaction is required for general chromatin ...[more]