Ontology highlight
ABSTRACT:
SUBMITTER: Kim YJ
PROVIDER: S-EPMC2689045 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Kim Yoo-Jin YJ Kim Yoon-Sang YS Larochelle Andre A Renaud Gabriel G Wolfsberg Tyra G TG Adler Rima R Donahue Robert E RE Hematti Peiman P Hong Bum-Kee BK Roayaei Jean J Akagi Keiko K Riberdy Janice M JM Nienhuis Arthur W AW Dunbar Cynthia E CE Persons Derek A DA
Blood 20090401 22
We previously reported that lentiviral vectors derived from the simian immunodeficiency virus (SIV) were efficient at transducing rhesus hematopoietic repopulating cells. To evaluate the persistence of vector-containing and -expressing cells long term, and the safety implications of SIV lentiviral vector-mediated gene transfer, we followed 3 rhesus macaques for more than 4 years after transplantation with transduced CD34+ cells. All 3 animals demonstrated significant vector marking and expressio ...[more]