Ontology highlight
ABSTRACT:
SUBMITTER: Birge RB
PROVIDER: S-EPMC2689226 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Birge Raymond B RB Kalodimos Charalampos C Inagaki Fuyuhiko F Tanaka Shinya S
Cell communication and signaling : CCS 20090510
The Crk adaptor proteins (Crk and CrkL) constitute an integral part of a network of essential signal transduction pathways in humans and other organisms that act as major convergence points in tyrosine kinase signaling. Crk proteins integrate signals from a wide variety of sources, including growth factors, extracellular matrix molecules, bacterial pathogens, and apoptotic cells. Mounting evidence indicates that dysregulation of Crk proteins is associated with human diseases, including cancer an ...[more]