Ontology highlight
ABSTRACT:
SUBMITTER: Mikhaylova M
PROVIDER: S-EPMC2690001 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Mikhaylova Marina M Reddy Pasham Parameshwar PP Munsch Thomas T Landgraf Peter P Suman Shashi Kumar SK Smalla Karl-Heinz KH Gundelfinger Eckart D ED Sharma Yogendra Y Kreutz Michael R MR
Proceedings of the National Academy of Sciences of the United States of America 20090519 22
Phosphatidylinositol 4-OH kinase IIIbeta (PI-4Kbeta) is involved in the regulated local synthesis of phospholipids that are crucial for trans-Golgi network (TGN)-to-plasma membrane trafficking. In this study, we show that the calcium sensor proteins calneuron-1 and calneuron-2 physically associate with PI-4Kbeta, inhibit the enzyme profoundly at resting and low calcium levels, and negatively interfere with Golgi-to-plasma membrane trafficking. At high calcium levels this inhibition is released a ...[more]